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Updated: Jun 24, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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关于因果效应分解为调解,相互作用和直接效应的指南:关于有氧运动和帕金森病的案例研究

Nina A Hilkens1, Gemma Hammerton1, Nienke M De Vries1

  • 1From the Department of Neurology (N.A.H., N.M.D.V., B.R.B., S.K.L.D.), Radboud University Medical Centre; Donders Institute for Brain, Cognition and Behaviour (N.A.H., N.M.D.V., B.R.B., S.K.L.D.), Nijmegen, the Netherlands; Population Health Sciences (G.H., Y.B.-S.), Bristol Medical School, University of Bristol; Medical Research Council Integrative Epidemiology Unit at the University of Bristol (G.H.), Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom; and Center of Expertise for Parkinson & Movement Disorders (N.M.D.V., B.R.B., S.K.L.D.), Nijmegen, the Netherlands.

Neurology
|June 10, 2024
PubMed
概括

四向分解方法通过考虑暴露和介质之间的相互作用,改善了医学研究中的因果关系分析. 这种方法提供了更准确的治疗途径和效果的理解,与传统的调解分析不同.

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