表观遗传年龄估计器与认知功能轨迹的关联在妇女健康倡议的记忆研究中
Steve Nguyen1, Linda K McEvoy1, Mark A Espeland1
1From the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
根据DunedinPACE (Dunedin Pace of Aging Calculated From the Epigenome) 的测量,表观遗传衰老与老年女性的认知衰退速度更快有关,特别是那些患有APOE ε4.4的女性. 这种生物标志物可以识别高风险的个体.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
背景情况:
- 表观遗传年龄估计与与年龄相关的健康结果相关.
- 表观遗传年龄和认知功能之间的纵向关联仍未得到充分研究.
研究的目的:
- 检查表观遗传年龄估计器与老年女性认知功能之间的纵向关联.
- 研究从表观基因组 (DunedinPACE) 计算的宁衰老步伐和其他表观基因标记在认知衰退中的作用.
主要方法:
- 从妇女健康倡议记忆研究中对795名老年女性进行了长度研究.
- 使用修改型迷你精神状态检查 (3MS) 和认知状态电话采访 (TICS-m) 进行年度认知功能评估.
- 计算了五种表观遗传年龄估计器,包括DunedinPACE,并使用线性混合效应模型进行分析.
主要成果:
- 在DunedinPACE的1-SD增加与TICS-m分数的年均下降速度更快有关.
- AgeAccelPheno在最小调整的模型中显示了与TICS-m衰退的类似关联.
- 较高的DNA甲基化基替代物GDF-15,β-2微球蛋白,cystatin C,TIMP-1和上腺素与更快的认知衰退相关.
结论:
- 较高的DunedinPACE与加速的认知衰退有关,特别是在APOE ε4载体中.
- DUNEDINPACE可以作为一种生物标志物,用于识别面临认知衰退风险的老年女性.
- 研究的局限性包括使用辅助研究数据,专注于全球性认知功能,而不是特定领域的认知功能.
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