相关实验视频
Updated: Jun 24, 2025

12:08
Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
18.5K
在中,多草药协同作用的方法:范围审查协议
Anjana Chandhiruthil Sathyan1, Pramod Yadav1, Prashant Gupta2
1Department of Rasa Shastra and Bhaishajya Kalpana, All India Institute of Ayurveda, Delhi, India.
JMIR research protocols
|June 10, 2024
概括
本范围审查协议概述了一种搜索策略,用于绘制传统医学中用于研究多草药配方 (PHFs) 的计算方法. 它旨在识别应用in silico方法的知识差距,以了解PHF活动.
科学领域:
- 计算生物学 计算生物学
- 药理学 药理学是指药理学的学科.
- 传统医学的传统医学.
背景情况:
- 全球超过80%的人口使用传统医学,通常依赖于多草药配方 (PHF).
- 对于PHFs的分子作用机制尚不清楚.
- 虽然计算方法已经在单一的草药中得到了进展,但它们对PHF的应用尚不清楚.
研究的目的:
- 制定一个全面的搜索策略,用于范围审查.
- 绘制全球使用的in silico方法,以了解PHFs在传统医学中的活性.
主要方法:
- 基于Arksey和O'Malley以及JBI建议的范围审查方法.
- 在五个数据库 (PubMed,Embase,Science Direct,Web of Science,Google Scholar) 中进行系统搜索.
- 使用Mendeley进行引用管理和Rayyan进行选,遵循PRISMA-ScR指南.
主要成果:
- 开发了一个三步式的搜索策略,最初产生了3865项研究.
- 过器和关键字精细化将研究列表减少到875个,以便进一步审查.
- 搜索策略被代性地改进,以提高相关性.
结论:
- 这项研究将确定PHF计算方法中的知识差距.
- 它将解决关于植物化学品,目标识别和PHFs的in silico战略的研究问题.
- 这些发现将增强对研究PHFs的in silico方法的理解.
关键词:
艾尔维达是一种阿育韦德.阿尤尔韦达系统是阿尤尔韦达系统.艾尔韦达医学是一种医药.艾尔维达治疗的治疗方法计算机辅助药物设计草本草药是一种草本草药.草药药物 草药药物是一种草药.在 silico 方法的方法.药学动力学上的药理学.药理学 药理学 药理学 药理学 药理学多草药配方 多草药配方范围审查 范围审查审查更多相关视频
相关概念视频
Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K
Structure-Activity Relationships and Drug Design
699
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
699
Drug Discovery: Overview
7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.8K
Agonism and Antagonism: Quantification
358
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
358

