相关实验视频

Updated: Jun 24, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

在黑色素瘤的预后和免疫疗法基于蛋白k相关的签名

Yang Liu¹, Huan Xia², Yongmei Wang¹

¹Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, School of Biology and Engineering (School of Modern Industry for Health and Medicine)/School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Immune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China.

International immunopharmacology

|June 10, 2024

概括

黑色素瘤中的高SELENOK水平与免疫细胞透率的增加和患者预后的改善相关. 一种基于SELENOK特征基因的新型风险模型有助于预测黑色素瘤的结果并指导治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

和蛋白在黑色素瘤的进展中起作用.
塞勒诺克对黑色素瘤脂质代谢,细胞内膜网膜应激 (ERS) 和免疫微环境的特定影响仍然在很大程度上未被探索.

研究的目的:

为了研究SELENOK在黑色素瘤中的作用.
分析SELENOK与预后,免疫细胞透,脂质代谢和ERS的关联.
开发和验证基于SELENOK特征基因的黑色素瘤患者的预后风险模型.

主要方法:

分析来自黑色素瘤患者的转录组数据.
研究SELENOK表达及其与临床结果的相关性.
构建和评估一个风险模型,包括ERS,脂质代谢和免疫相关基因.
对不同风险群体进行药物敏感性分析.

主要成果:

黑色素瘤中较高的SELENOK表达与免疫细胞透率的增加和更好的预后有关.
在黑色素瘤中,SELENOK会影响ERS,脂质代谢和免疫细胞透.
基于SELENOK的风险模型准确地预测了黑色素瘤的预后.
低风险患者表现出有利的免疫微环境,并对标准化疗有反应,而高风险患者可能受益于RAS途径抑制剂.

结论:

在黑色素瘤中,SELENOK是ERS,脂质代谢和免疫透的关键调节者.
SELENOK表达与黑色素瘤预后有积极的关联.
开发的风险模型对于预测黑色素瘤预后和为个性化治疗决策提供信息是有价值的.

关键词:

细胞内膜网膜应激压力免疫系统的透.脂质新陈代谢脂质新陈代谢黑色素瘤是一种黑色素瘤.蛋白K是一种K蛋白.

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...