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Ana Ubago-Rodríguez^1,2,3,4, María I Quiñones-Vico^5,6,7,8, Manuel Sánchez-Díaz^6,9

¹Cell Production and Tissue Engineering Unit, Virgen de Las Nieves University Hospital, Granada, Spain, aur@ugr.es.

Dermatology (Basel, Switzerland)

|June 10, 2024

概括

本综述总结了牛皮研究的临床前模型,强调体外3D模型是减少动物使用最有希望的. 这些模型有助于开发更安全,更有效的牛皮治疗方法.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
临床前研究临床前研究

背景情况:

牛皮是一种具有复杂免疫遗传基础的慢性炎症性皮肤病.
了解牛皮的发病因子对于开发新疗法至关重要.
有效的药物开发依赖于具有良好的特征的临床前模型.

研究的目的:

系统地审查目前牛皮研究的临床前模型.
讨论这些模型的发展,优势,局限性和应用.

主要方法:

在PubMed和Scopus上进行了系统的文献搜索.
在选择文章时,遵循了PRISMA指南.
精选的文章集中在体内,体外和体外牛皮病模型上.

主要成果:

45篇原创文章被选中进行审查.
体外模型,特别是3D培养,由于易于使用和人皮肤相似性,最为普遍.
化学诱导的伊米基莫德模型在体内是常见的,而体外模型是最不常用的.

结论:

目前的临床前模型提供了有价值的见解,但面临着发展挑战.
3D生物打印和器官芯片技术的进步显示了未来牛皮研究的前景.
越来越多地使用体外模型可以减少牛皮研究中的动物试验.

关键词:

动物模型动物模型生物工程皮肤生物工程皮肤在ex vivo模型中.临床前模型是临床前模型.牛皮是一种病.

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