使用多层可拆卸的微针将短作用胰岛素转化为热稳定的长效胰岛素
Theerapat Phoka1, Nisha Wanichwecharungruang2, Narintorn Dueanphen1
1Center of Excellence in Materials and Bio-Interfaces, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Journal of pharmaceutical sciences
|June 10, 2024
概括
可拆卸的溶解微针 (DDMN) 提高了胰岛素的储存稳定性和输送. 这些微针可提供增强的热稳定性和高效的透皮输送,用于糖尿病管理.
科学领域:
- 生物材料科学 生物材料科学
- 制药科学 制药科学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病胰岛素治疗需要有效的输送和稳定的配方.
- 目前的胰岛素输送方法面临着稳定性和患者服药性方面的挑战.
- 微针技术为通过皮肤递送药物提供了一个有希望的替代方案.
研究的目的:
- 开发和表征可拆卸的溶解微针 (DDMN),以改善胰岛素的输送.
- 为了提高胰岛素的热稳定性和储存,使用微针配方.
- 评估胰岛素载体DDMN的体外和体内疗效.
主要方法:
- 制造多层载有胰岛素的DDMN,其中包括氨酸和酸.
- 使用差分扫描热度计,在DDMN矩阵内评估胰岛素的热稳定性.
- 对糖尿病大鼠的ex vivo皮肤透和体内药理动力学研究的评估.
主要成果:
- 胰岛素-DDMN显示显著增强的热稳定性,胰岛素变性温度增加到186°C.
- 通过使用ex vivo猪皮实现了91±1.59%的高体外输送效率.
- 在糖尿病大鼠的体内研究显示,与皮下注射相比,胰岛素释放持续,降血糖发作延迟,持续时间延长.
结论:
- 胰岛素-DDMN提供了一个稳定高效的平台,可以通过皮肤输送胰岛素.
- 这种微针系统通过增强胰岛素稳定性和受控释放提供了改善糖尿病管理的潜力.
- 无针式胰岛素注射DDMN代表了无针式胰岛素注射技术的有希望的进步.
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