Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

92
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
92
Randomized Experiments01:13

Randomized Experiments

6.9K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.9K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Blind Procedures02:07

Blind Procedures

10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Blinding01:11

Blinding

2.4K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Looking back to look forward: can analytical performance be successfully linked to health outcomes in laboratory medicine?

Clinical chemistry and laboratory medicine·2026
Same author

Experiences of patient-led melanoma surveillance and teledermatology in underserved groups in the Melanoma Self-Surveillance Trial: A qualitative sub-study.

Journal of telemedicine and telecare·2026
Same author

Time-to-progression ratio as a potential study endpoint in early-phase oncology trials: pooled analysis of phase II trials from the Australian MoST program.

Future oncology (London, England)·2026
Same author

Mind the Gap: Impact of New Labels on Public Perceptions and Calculated Risk of Adverse Outcomes after a Melanoma In Situ Diagnosis-A Secondary Analysis of an Online Randomized Experiment.

Medical decision making : an international journal of the Society for Medical Decision Making·2026
Same author

Strengths-based resilience: the biopsychosocial factors that differentiate 12-year mental well-being trajectories following adverse childhood experiences.

Psychological medicine·2026
Same author

The carbon footprint of surgical and non-surgical skin cancer appointments.

Clinical and experimental dermatology·2026

相关实验视频

Updated: Jun 24, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

解决随机对照试验中缺少的结果数据的问题:方法论范围审查

Ellie Medcalf1, Robin M Turner2, David Espinoza3

  • 1Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Contemporary clinical trials
|June 10, 2024
PubMed
概括
此摘要是机器生成的。

处理随机对照试验 (RCT) 中缺少的结果数据的强有力的方法至关重要. 本综述强调了分析方法,特别是对于不随机丢失的数据 (MNAR),以提高试验有效性.

关键词:
这是一个偏见的偏见.缺少的数据数据.随机对照试验是随机对照试验.范围审查 范围审查统计方法 统计方法试验结果 试验结果

更多相关视频

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

494
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.3K

相关实验视频

Last Updated: Jun 24, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

494
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.3K

科学领域:

  • 临床试验方法论 临床试验方法论
  • 生物统计学 生物统计学
  • 数据分析 数据分析

背景情况:

  • 在临床试验中,缺少结果数据很普遍.
  • 目前的方法通常依赖于过于严格的完全随机缺失 (MCAR) 假设.
  • 需要强大的方法,适合各种缺失数据场景.

研究的目的:

  • 系统地审查和总结有关在随机对照试验 (RCT) 中处理缺失结果数据的分析方法的文献.
  • 强调适用于数据缺失随机 (MAR) 和缺失不随机 (MNAR) 假设的方法.
  • 为试验人员提供有关选择合适方法的指导.

主要方法:

  • 进行了一项方法论范围审查.
  • 从2015年1月到2023年3月,在四个主要数据库 (MEDLINE,Embase,CENTRAL,CINAHL) 进行了搜索.
  • 前向和后向引用搜索补充数据库搜索以确定讨论RCT中缺少数据的方法或框架的合格论文.

主要成果:

  • 从1878个选记录中确定了101篇符合条件的论文.
  • 大多数 (89%) 描述了具体的方法,而11% 提出了框架.
  • 对MNAR数据的方法最常被探索 (53%),其次是MAR数据 (33%),在MNAR下基于控制的方法是最常见的.

结论:

  • 本综述为缺少结果数据的分析方法提供了指导,重点关注MNAR假设.
  • 这些发现旨在帮助试验人员使用合适的方法来解决缺失的数据.
  • 更好地处理缺失的数据可以提高RCT发现的可靠性和有效性.