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Updated: Jun 24, 2025

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由iPSC衍生的脑细胞构建的人类-小鼠模拟大脑模型:应用和挑战

Ya Zhao1, Ke Liu2, Yinghua Wang3

  • 1Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China.

Experimental neurology
|June 10, 2024
PubMed
概括

人类诱导的多能干细胞 (iPSC) 用于创建用于研究大脑疾病的仿真脑模型. 这些模型有助于了解疾病机制,并开发新的细胞移植疗法.

关键词:
脑细胞 脑细胞 脑细胞基梅里克鼠标模型模型区分 区分 区分 区分功能 功能 功能 功能人类诱导的多能干细胞干细胞.整合 整合 整合

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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