叉头盒M1的表达和FOXM1抑制在上皮质肉瘤中的抗癌作用
Yuichi Shibui1, Kenichi Kohashi2, Yuko Hino3
1Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba Hospital, Ibaraki, Japan.
概括
表皮状肉瘤 (ES) 显示FOXM1基因的高表达,这是瘤生长和转移的潜在驱动因素. 在细胞系中抑制FOXM1减少了扩散和入侵,这表明它是治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 表皮状肉瘤 (ES) 是一种罕见的,具有高复发和转移倾向的侵袭性软组织肉瘤.
- 迫切需要新的治疗策略来有效治疗ES.
- 叉头盒转录因子1 (FOXM1) 因其致癌功能和频繁过度表达而与各种癌症有关.
研究的目的:
- 为了研究ES标本中FOXM1的表达水平.
- 分析在ES中FOXM1表达的临床,临床病理学和预后意义.
- 探索在ES细胞系中准FOXM1的治疗潜力.
主要方法:
- 在38个ES标本中对FOXM1表达的免疫组织化学分析.
- 对FOXM1表达和临床病理特征 (瘤大小,年龄,性别,主要部位,组织学,深度,存活率) 之间的相关性分析.
- 在体外研究中,使用用FOXM1siRNA和斯特治疗的ES细胞系来评估对增殖,耐药性,迁移,入侵和细胞周期的影响.
主要成果:
- 所有38个ES标本都对FOXM1表达呈阳性.
- 高FOXM1表达与较大的瘤大小显著相关 (P = .013).
- 在ES细胞系中对FOXM1的下调抑制了增殖,增强了药物敏感性,减少了迁移和入侵,并诱导了细胞循环停止. 发现FOXM1可以调节cIAP2,这是一个亡抑制剂.
结论:
- 在上皮状肉瘤中,FOXM1 持续过度表达,与瘤大小相关.
- 通过抑制 (例如,用列) 向FOXM1,在ES细胞系中显示出抗癌效应.
- 福克斯M1代表了一种有前途的治疗瘤的治疗标.
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Induced Pluripotent Stem Cells
4.0K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.0K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K


