移动过量反应计划:在费城的一个移动,低值的阿片类药物使用障碍治疗模式
Margaret Lowenstein1, Ellena Popova2, Aminata Jalloh3
1Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.
Journal of substance use and addiction treatment
|June 10, 2024
概括
低门移动治疗改善了边缘化个体获得布普伦诺芬的机会. 由移动医生配备的诊所的内部转诊显著增加了阿片类药物使用障碍 (OUD) 的成功护理联系.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 移动卫生干预行动 移动卫生干预行动
背景情况:
- 低门物质使用治疗计划可以减少边缘化人口的障碍.
- 移动外展服务为启动和稳定布普伦诺芬治疗提供了一条途径.
- 基于街道的布普伦诺芬启动解决了服务不足社区的关键需求.
研究的目的:
- 描述费城一个移动的街头布普伦诺啡因计划的参与者和治疗结果.
- 检查与成功连接与阿片类药物使用障碍 (OUD) 患者持续护理相关的因素.
主要方法:
- 对237名通过移动过量反应计划 (9/2020-12/2021) 接受布普伦诺芬的患者进行了回顾性队列研究.
- 电子医疗记录数据抽象患者特征,移动治疗和护理联系.
- 多变量后勤回归分析以确定成功护理联系的预测因素.
主要成果:
- 该计划服务于多元化的人口,平均年龄为46岁,主要是男性 (67%),黑人 (59%) 和白人 (33%) 个人占有很大比例.
- 大多数参与者有OUD (87%的海洛因/芬太尼使用),高水平的静脉药物使用 (37%) 和低基线参与传统护理.
- 观察到高移动程序参与度 (≥1次访问:86%,≥4次访问:69%),其中51%参加了场外活动,30%接受了≥2次布诺芬处方.
- 对大学诊所的内部转诊显著增加了有效护理联系的几率 (aOR 2.47).
结论:
- 基于社区的移动外展有效地让OUD的边缘化个体参与物质使用治疗.
- 虽然移动程序的保留率很高,但与外部护理的联系有所不同.
- 由移动单位医生配备的诊所的转诊成为成功长期护理联系的关键预测因素.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
276
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
276
Drug Abuse and Addiction: Pharmacological Phenomena
465
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
465
Opioid Analgesics: Morphine and Other Natural Cogeners
234
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
234
Analgesia and Pain Management
579
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
579
Prescription, Nonprescription and Orphan Drugs
720
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
720
Opioid Receptors: Overview
729
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
729


