职业化学品安全下一代风险评估 - 用二二乙烯硫酸盐作为现实世界的例子
Adam Wood1, Catherine Breffa2, Caroline Chaine3
1Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Toxicology
|June 10, 2024
概括
下一代风险评估 (NGRA) 提供了一种使用新方法方法 (NAMs) 评估工人安全的新方法. 这项研究表明,NGRA可以应用于职业环境,减少对乙酸等化学物质的动物试验.
科学领域:
- 毒理学和风险评估
- 职业健康和安全问题 职业健康和安全问题
- 在 Vitro 和 In Silico 方法.
背景情况:
- 下一代风险评估 (NGRA) 使用新方法方法 (NAM) 进行安全评估.
- 目前的NGRA应用有限,主要用于化品,而不是职业安全评估 (例如,欧盟REACH).
- 工人安全评估在很大程度上依赖于动物试验,强调需要使用替代方法.
研究的目的:
- 开发和说明一个工作流程,以在职业安全背景下进行NGRA.
- 评估使用NGRA的工人对二乙醇硫酸盐 (SI) 的安全性.
- 证明非动物试验方法的整合用于监管人员安全评估.
主要方法:
- 在职业环境中为NGRA开发了一个分层和代的工作流.
- 使用暴露建模和SI的生命周期评估估计的职业暴露.
- 使用生理基动力学 (PBK) 建模与SI特定的ADME数据来估计内部暴露.
- 使用一个涵盖系统性,生殖性和发育性毒性的NAM小组评估SI生物活性.
主要成果:
- PBK建模预测SI在整个生命周期中最坏情况下的血Cmax为0.8μM.
- SI生物活性测试产生了从104到5044μM的起点 (PoD).
- 计算的生物活性暴露比率 (BER) 表示在当前暴露水平下,对工人的安全性.
结论:
- 开发的NGRA工作流适用于职业安全评估,减少对动物试验的依赖.
- 这种方法支持动物试验只能作为最后手段的原则.
- NGRA的整合可以提高化学品工人安全评估的效率和伦理考虑.
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