接种COVID-19疫苗和月经之间的关联:科学审查的现状
Laura A Payne1,2, Lauren A Wise3, Amelia K Wesselink3
1McLean Hospital, Belmont, Massachusetts, USA LPayne@mclean.harvard.edu.
BMJ sexual & reproductive health
|June 10, 2024
概括
接种COVID-19疫苗与月经周期和疼痛的暂时变化有关. 未来的疫苗研究应该严格评估月经健康,以了解这些影响并改善女性的整体状况.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 月经健康是整体健康和生育能力的关键指标.
- 作为COVID-19疫苗临床试验的结果,月经功能显著缺席.
- 了解COVID-19疫苗接种对月经的影响对于患者的健康至关重要.
研究的目的:
- 系统地审查和综合有关COVID-19疫苗接种和月经健康结果之间的关系的现有文献.
- 巩固当前关于疫苗对月经周期产生的影响的证据.
主要方法:
- 进行了全面的PubMed搜索,截至2023年10月31日.
- 包括53篇出版物,包括前性队列,后性队列,基于注册表的队列,横截面和病例控制研究.
- 由于设计局限性,在确定的研究中存在中等至高的偏差风险.
主要成果:
- 大多数研究表明,COVID-19疫苗接种与月经周期长度,流量和疼痛的变化之间存在临时联系.
- 在卵泡期内接种疫苗与周期长度的显著增加有关.
- 观察到的影响包括青少年的暂时月经变化,绝经后个体的异常出血,以及荷尔蒙避孕的潜在益处.
结论:
- 有证据支持COVID-19疫苗接种与月经健康结果之间的关联.
- 建议将月经作为未来所有疫苗试验的关键结果.
- 在未来的研究中主张严格评估月经周期,以最大限度地减少偏见并探索生物机制.
相关概念视频
Disorders of the Female Reproductive System
352
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
352
Hormonal Regulation of the Menstrual Cycle
342
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
342
Vaccinations
44.4K
Overview
44.4K
Birth Control Methods
230
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
230
The Menstrual Cycle
772
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
772
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K


