相关实验视频
Updated: Jun 24, 2025
06:01
Fluorescence Lifetime Macro Imager for Biomedical Applications
Published on: April 7, 2023
739
光终身成像与距离和范围使用小型化的SPAD系统
Andrew B Matheson1, Charlotte Hopkinson2, Michael G Tanner3
1School of Engineering, Institute for Integrated Micro and Nano Systems, University of Edinburgh, Edinburgh, EH9 3FF, UK. a.matheson@ed.ac.uk.
Scientific reports
|June 10, 2024
概括
这项研究介绍了最小的芯片上的尖端广场光成像系统,能够进行高速成像和同时光终身成像距离和范围 (FLImDAR). 微型系统在生物组织中展示了材料对比度和场景重建.
科学领域:
- 生物医学工程 生物医学工程
- 光学成像技术的成像
- 光子学 是一个光子学.
背景情况:
- 微型成像系统对于现场诊断和研究至关重要.
- 时隔单光子雪崩二极管 (SPAD) 阵列提供先进的成像功能.
- 现有的系统往往缺乏可移植性和多模式功能.
研究的目的:
- 开发和演示一个紧的,芯片上的尖端成像系统.
- 为了实现高率广场光成像 (WFLIm).
- 整合同时的WFLIm和飞行时间测量 (FLImDAR).
主要方法:
- 使用了小型化的"芯片在尖端"系统,并配备了时门式SPAD阵列.
- 开发了两个系统版本,具有不同的视野和工作距离.
- 在材料对比度和绵羊肺组织自光学上测试了WFLIm.
- 评估FLImDAR用于3D对象分离和场景重建.
主要成果:
- 在WFLIm模式下实现的率>2Hz,具有材料对比度.
- 获得WFLIm图像的绵羊肺自光在1Hz.
- 使用FLImDAR证明了4毫米分辨率用于对象分离.
- 成功地在肺组织上进行了现场重建.
结论:
- 开发的系统是迄今出版的最小的芯片上尖端WFLIm系统.
- 这项工作代表了FLImDAR技术的第一个紧,便携式演示.
- 该系统显示了高级生物医学成像应用的巨大潜力.
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