物理非克隆功能的电子喷雾沉积用于药物防伪
Bryce J Kingsley1, J David Schaffer2, Paul R Chiarot3
1Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY, 13902, USA.
假冒药物对健康构成严重风险. 本研究介绍了适用于平板电脑的可食用物理非克隆功能 (ePUF),提供一种低成本,100%准确的使用机器视觉的护理点认证方法.
科学领域:
- 制药分析 制药分析
- 材料科学是一种材料科学.
- 生物医学工程 生物医学工程
背景情况:
- 制药假冒是一个重大的全球健康危险.
- 现有的药物认证方法往往缺乏治疗点的适用性和成本效益.
- 需要一个强大的,低成本的解决方案,以在患者层面验证药物的真实性.
研究的目的:
- 开发和评估可食用的物理非克隆功能 (ePUFs) 用于药品认证.
- 为了证明使用电子喷雾沉积的可行性,在药物片上创建独特的,可食用的安全模式.
- 建立一个可靠的ePUF认证的机器视觉系统.
主要方法:
- 电子喷雾沉积可食用油墨,在药物片上创建随机图案 (ePUF).
- 系统地改变工艺参数 (流量,转换速度,悬浮度) 以控制ePUF特性.
- 开发一种机器视觉认证算法,使用尺度不变特征转换 (SIFT) 模式匹配算法.
- 在不同的成像条件下,使用200个ePUF测试身份验证准确性.
主要成果:
- 在药物片上成功制造出独特的,随机的ePUF,使用电子喷雾沉积.
- 在将ePUF的手机图像与存储的数据库匹配时,实现了100%的身份验证成功率.
- 证明了认证算法的稳定性,以应对照明和图像方向的变化.
结论:
- 可食用PUF提供了一个有前途的,低成本的,高精度的解决方案,用于医疗保健点的药品认证.
- 电子喷雾沉积提供了精确的控制,用于创建独特的可食用安全标记.
- 开发的机器视觉系统能够对ePUF进行可靠和强大的身份验证,打击假冒药品.
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