植物酸盐代谢是由肠道微生物群中的微生物交叉食介导的
Willem M De Vos1, Minh Nguyen Trung2,3, Mark Davids4
1Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands.
Nature microbiology
|June 10, 2024
概括
肠道细菌Mitsuokella jalaludinii有效地降解植物酸盐,产生酸 (一个短链脂肪酸) 与Anaerostipes rhamnosivorans. 这种微生物发酵可能解释了植物酸盐的存在.
科学领域:
- 微生物学 微生物学
- 代谢工程是代谢工程.
- 营养科学 营养科学
背景情况:
- 食用植物酸盐提供健康益处,但其肠道微生物代谢的理解很差.
- 之前的研究表明,肠道微生物群将花酸转化为短链脂肪酸 (SCFA).
- 参与植物酸盐降解的特定微生物物种和代谢途径尚不清楚.
研究的目的:
- 为了确定负责人类肠道中植物酸盐降解的微生物物种.
- 为了阐明植物酸盐分解的代谢途径.
- 调查微生物植物酸盐代谢在产生有益的SCFA如酸盐中的作用.
主要方法:
- 使用已识别的微生物物种进行植物酸盐降解试验.
- 代谢和转录分析以确定代谢途径.
- 同位素标记 (13C) 在体外和体内 (小鼠) 的研究.
- 对人类肠道微生物组数据的分析.
主要成果:
- Mitsuokella jalaludinii被确定为一个关键的植物酸盐降解剂,与Anaerostipes rhamnosivorans一起工作.
- 在M. jalaludinii中阐明了一条完整的植物酸盐降解途径,产生3-基酸.
- 两种物种在试验室和小鼠中都证实了3 - 基酸转化为酸的协同作用.
- 这种植物是Mitsuokella spp. 发现它们在人类肠道微生物群中普遍存在.
- 在暴露于共同培养的超水生物的Caco-2细胞中观察到肠道屏障完整性的改善.
结论:
- 肠道微生物群,特别是M. jalaludinii和A. rhamnosivorans,在代谢食植物酸盐方面发挥着重要作用.
- 这些细菌将花酸盐发酵为酸盐,可能有助于与花酸盐消费相关的健康益处.
- 了解这种途径为基于微生物组的干预措施开辟了道路,以提高营养素的生物可用性和肠道健康.
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