在健康个体和多发性硬化症患者的宫脊髓MRI形态学中的生物变异
Sarah R Cook1,2, Kritin Vasamreddy1, Anna Combes1,3
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
概括
性别,年龄和身高显著影响脊髓 (SC) MRI 形态学,但体重没有. 控制这些因素对于在多发性硬化症 (MS) 等疾病中进行精确的SC形态测量研究至关重要.
科学领域:
- 神经成像是一种神经成像.
- 脊髓形态学 脊髓形态学
- 多发性硬化症研究研究
背景情况:
- 关于性别,年龄和身高如何影响脊髓 (SC) MRI 形态学,存在相互矛盾的文献.
- 以前的研究表明,体重不会显著影响SC形态学.
- 了解这些生理变异是解释临床SC形态测量数据的关键.
研究的目的:
- 调查宫SCMRI形态参数与生物变量 (年龄,性别,身高,体重) 之间的关联.
- 确定这些变量作为多发性硬化症 (MS) 研究中的潜在混因素的作用.
- 为了比较健康志愿者的SC形态与MS患者.
主要方法:
- 病例控制研究涉及69名健康志愿者和31名MS患者.
- 宫SCMRI在3特斯拉获得,以C3/C4.4为中心.
- 使用脊髓工具箱 (v4.0.2) 进行图像处理;通过混合效应线性回归进行分析.
主要成果:
- 性别,年龄和身高显著影响和灰质 (GM) 截面积 (CSA) 和GM:CSA比.
- 体重与SC形态参数没有显著关联.
- 在对其他变量进行控制后,MS疾病持续时间对C4CSA产生了显著影响.
结论:
- 性,年龄和身高是重要的生理变量,必须在SC形态测量研究中进行控制.
- 考虑到这些因素对于准确评估与疾病相关的变化至关重要,特别是在MS中.
- 未来的SC形态测量研究应该纳入这些生物共变量,以最大限度地减少混.
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