调节SETD2维持巨细胞的免疫调节功能,以抑制气道过敏
Lei Zhang1, Junyi Wang1, Xiaoyu Liu2,3
1Laboratory of Allergy and Precision Medicine, Department of Pulmonary and Critical Care Medicine, Chengdu Institute of Respiratory Health, the Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
Immunology
|June 11, 2024
概括
含SET域2 (SETD2) 调节巨细胞的免疫特性. 它在巨细胞中的耗尽会导致Th2炎症,突出显示SETD2.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 含有SET域2 (SETD2) 是一种通过H3K36me3.3调节基因转录的基因甲基转移酶.
- 巨细胞 (Mφs) 是关键的免疫细胞,参与炎症和调节反应.
- 在巨细胞免疫功能中SETD2的特定作用,特别是在呼吸道炎症中,仍然不清楚.
研究的目的:
- 阐明SETD2在调节巨细胞免疫性质中的作用.
- 研究呼吸道巨中SETD2表达和过敏性喘之间的关联.
- 为了确定SETD2枯竭对肺部巨细胞介导免疫反应的影响.
主要方法:
- 使用流细胞计和RNA测序,从支气管洗液 (BALF) 中分离和分析巨细胞 (Mφs).
- 使用SETD2缺乏Mφs的小鼠模型和已建立的呼吸道过敏小鼠模型 (卵/协议).
- 评估对SETD2枯竭和过敏敏感化的反应中的肺炎和免疫细胞概况.
主要成果:
- 在过敏性喘患者的气道Mφs和在小鼠过敏敏感化期间的M2细胞中观察到SETD2表达的减少.
- 在M2细胞中SETD2表达与喘临床反应相关.
- 在Mφs中SETD2的枯竭导致肺部的Th2模式炎症,损害了气道M2细胞的免疫调节功能.
结论:
- 在维持呼吸道巨细胞,特别是M2细胞的免疫调节性质方面,SETD2发挥着至关重要的作用.
- 巨细胞中SETD2表达的降低与过敏喘的发病和Th2驱动的肺炎有关.
- 向SETD2可能为管理过敏呼吸道疾病提供治疗策略.
相关概念视频
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K


