多发性骨髓瘤患者的骨相关事件:一个全面的回顾性队列研究
Ji Yun Lee1, Ju-Hyun Lee1, Jeongmin Seo1
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Journal of Korean medical science
|June 11, 2024
概括
骨相关事件 (SREs) 影响了近一半的多发性骨髓瘤 (MM) 患者,风险因素包括女性性别,年龄较大和某些化疗方案. 这项研究强调了在MM患者中需要主动评估骨健康的必要性.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 多发性骨髓瘤 (MM) 患者面临与骨相关事件 (SREs) 的显著风险,例如骨折和骨手术.
- 关于MM患者SRE发病率和风险因素的现实数据有限.
研究的目的:
- 调查韩国MM患者的大量队列中SRE的发生率和确定风险因素.
- 为MM患者的骨健康评估和管理提供见解.
主要方法:
- 一项回顾性,全国性的队列研究,利用韩国医疗保险审查和评估服务 (HIRA) 数据库从2007年到2018年.
- 对6717名被诊断为有症状的MM患者的分析,随访时间中位数为35.1个月.
主要成果:
- 43.6%的MM患者经历了SRE,其中20.0%在第一年内患有病理骨折.
- 第一次SRE的中位时间为9.6个月.
- 有关SRE的危险因素包括女性性别,年龄≥50,脑血管疾病,不使用博特佐米布/莱纳利多米德的化疗,以及之前使用双酸盐的SRE.
结论:
- 这是第一项基于人群的研究,报告了韩国MM患者的SRE发病率和风险因素.
- 这些发现可以为MM患者的骨健康管理策略提供信息.
- 了解这些风险因素对于早期干预和改善患者结果至关重要.
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