基于循环德克斯特林纳米聚合物的氧化的超和药物输送系统:制备,表征和体内应用
Ziwei Huang1, Shanli Zhang1, Zehui Qin1
1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
International journal of nanomedicine
|June 11, 2024
概括
氧基柏林 (OBB) 超和药物递送系统 (SDDS) 与基基-β-环极 (HP-β-CD) 显著增强了OBB.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 代谢学 代谢学 代谢学
背景情况:
- 柏柏林的代谢物氧柏林 (OBB) 显示出抗高尿素活性.
- 低溶解度和生物利用度限制了OBB的治疗潜力.
- 开发先进的药物输送系统对于OBB利用至关重要.
研究的目的:
- 开发和表征一种OBB-基基β-环德素 (HP-β-CD) 超和药物递送系统 (SDDS).
- 通过开发的SDDS来评估OBB的增强溶解性,溶解性和生物可用性.
- 在体内评估OBB-HP-β-CD SDDS改善的抗超血性疗效.
主要方法:
- 使用超声波溶剂蒸发的OBB-HP-β-CD SDDS的制备.
- 使用FT-IR,DSC,PXRD,NMR和分子建模的复合体的表征.
- 在体外和体内释放的研究,药理动力学分析和药理动力学测定.
主要成果:
- 形成一个无形的OBB-HP-β-CD复合体,增强稳定性和纳米聚合物形成 (23纳米).
- OBB溶解率增加了5倍,口服生物利用率提高了16倍.
- 显著增加AUC (10.882微克/毫升*小时对比0.701微克/毫升*小时) 和5-10倍更高的抗高尿素血功效.
结论:
- OBB-HP-β-CD SDDS有效地克服了OBB的可溶性和生物利用性限制.
- 开发的SDDS在治疗高尿血症方面表现出卓越的疗效.
- 该系统代表了一种有前途的方法,以加强OBB的制药开发.
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