在骨髓缺陷中,骨免疫相互作用和TH-1/TH-2比:一个被低估的关联 - 原始研究
Johann Lechner1, Volker von Baehr2, Florian Notter1
1Clinic for Integrative Dentistry, Munich, Germany.
Biologics : targets & therapy
|June 11, 2024
概括
在骨缺陷 (BMDJ/FDOJ) 中的慢性骨质免疫失调与受损的Th1/Th2免疫平衡和减少伤口愈合有关. 解决Th1/Th2比率对于手术结果至关重要.
科学领域:
- 骨质免疫学 骨质免疫学
- 免疫学 免疫学 免疫学
- 在口腔外科手术中.
背景情况:
- 慢性骨质免疫失调的特征是下巴骨髓缺陷 (BMDJ),呈现为脂肪退行性骨硬化 (FDOJ).
- 与健康的骨相比,BMDJ/FDOJ表现出改变的细胞因子配置,包括下调的TNF-α和IL-6,以及RANTES/CCL5的过度表达.
研究的目的:
- 研究BMDJ/FDOJ的骨免疫缺陷,不完全的伤口愈合和Th1/Th2比率之间的关系.
- 在患有BMDJ/FDOJ和免疫疾病的患者中评估调节性T细胞 (T-reg) 表达.
主要方法:
- 来自128名BMDJ/FDOJ患者的骨样本的细胞因子分析.
- 在197名患有免疫疾病的BMDJ/FDOJ患者的对照组中确定血清IFN-γ和IL-4度和Th1/Th2比率.
主要成果:
- 超过80%的对照组 (167/197) 显示Th2转移,Th1/Th2比率<6.1,表明免疫调节受损.
- 30%的受试者 (47/197) 表现出过度的T-reg过度活化 (>1,900 pg/mL),这表明免疫活性受到强烈的下调.
- BMDJ/FDOJ的特点是缺乏Th1细胞因子和过度表达RANTES/CCL5和IL-1ra,与急性炎症模式形成鲜明对比.
结论:
- BMDJ/FDOJ与Th1缺乏,过度的RANTES/CCL5和IL-1ra以及受损的伤口愈合有关.
- Th1/Th2比率和T-reg水平是BMDJ/FDOJ病变发生的关键因素.
- 对于牙科手术来说,要更好地考虑Th1/Th2比率,以防止BMDJ/FDOJ的发展,这是必不可少的.
更多相关视频
07:51Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
Published on: March 18, 2019
6.0K
12:23Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
19.6K
相关概念视频
Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Formation by Intramembranous Ossification
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
