在接受新辅助化疗的乳腺癌患者中,使用intravoxel不连贯运动和动态对比增强MRI测量的参数之间的关系:一个纵向队列研究
Zyad M Almutlaq1,2, Sarah E Bacon3, Daniel J Wilson3
1Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, United Kingdom.
Frontiers in oncology
|June 11, 2024
概括
在乳腺瘤 perfusion.Intravoxel不连贯运动 (IVIM) MRI 与动态对比增强 (DCE) -MRI 没有相关性. 然而,扩散MRI测量显示了与间歇性和细胞外体积分数的中等相关性,支持它们与水扩散的关系.
科学领域:
- 放射学和医学成像学 医学成像学
- 在瘤学瘤学.
- 生物物理学的生物物理.
背景情况:
- 动态对比增强型MRI (DCE-MRI) 是评估乳腺瘤输液的标准.
- 输入素不连贯运动 (IVIM) MRI 提供了一个潜在的无对比剂替代品.
- 了解扩散和 perfusion 参数之间的关系对于癌症评估至关重要.
研究的目的:
- 评估IVIM作为DCE-MRI对乳腺瘤输液测量的无对比剂替代品.
- 调查扩散MRI (DWI) 参数与DCE-MRI衍生的组织体积分数之间的相关性.
主要方法:
- 分析了来自40名原发性乳腺癌患者的108个配对DWI和DCE-MRI扫描.
- 扫描是在治疗前和在新辅助化疗 (NACT) 期间获得的.
- 分析的主要参数包括ADC,Dt,DP,f,f×DP (IVIM) 和Fb,vb,ve,vd (DCE-MRI).
主要成果:
- 在IVIM和DCE-MRI perfusion参数 (f与vb,f×Dp与Fb) 之间没有发现显著的相关性.
- 在整个瘤区域观察到ADC/Dt和ve/vd之间的中等正相关性.
- 同时,ADC/Dt和ve/vd之间的个体内相关性也显著.
结论:
- 在乳腺瘤中,IVIM参数 (f,f×Dp) 不是DCE-MRI perfusion参数 (vb,Fb) 的可靠替代品.
- 扩散 (ADC,Dt) 和间位体/细胞外体积 (ve,vd) 之间观察到的相关性支持了它们的生物学关系.
- 需要进一步的研究来澄清IVIM在乳腺癌成像中的差异和潜力.
关键词:
乳腺癌 乳腺癌 乳腺癌关联关系的相关性.动态对比增强的核磁共振成像在intravoxel不连贯的运动.perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这种方法通常被认为是最常见的方法之一,因为它可以让一个人的身体变得更加舒适,可以让一个人的身体变得更加舒适.反复采取措施反复采取措施.更多相关视频
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