微观结肠炎继发于勒弗卢诺米德:一个病例报告
Mohamed A Ebrahim1, Eli A Zaher1, Parth Patel1
1Internal Medicine, Ascension Saint Joseph Hospital, Chicago, USA.
Cureus
|June 11, 2024
概括
微观性结肠炎是导致慢性腹的原因,在开始服用莱夫卢诺米德后,一种类风湿性关节炎患者被诊断出患有这种疾病. 停止服用该药物可以缓解症状,这表明莱夫卢诺胺是这种罕见疾病的可能原因.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微观性结肠炎 (MC) 呈现为慢性水性腹,通过组织学诊断.
- 类风湿性关节炎 (RA) 患者可能会经历药物的胃肠道副作用.
研究的目的:
- 报告一个极其罕见的leflunomide诱导的微观结肠炎病例.
- 强调在无法解释的腹中考虑药物因果关系的重要性.
- 突出结肠活检在MC中的诊断作用.
主要方法:
- 一个63岁女性的病例报告与RA在莱夫卢诺米德.
- 尽管结肠镜检查正常,但持续性腹的临床表现.
- 通过随机结肠活检确认MC.
主要成果:
- 勒弗卢诺米德的开始先于慢性水性腹的开始.
- 结肠活检的组织学检查证实了微观性结肠炎.
- 停用莱夫卢诺米德导致症状完全消失.
结论:
- 勒弗卢诺米德可以诱导微观结肠炎,这是一个罕见但显著的不良影响.
- 彻底的药物历史和药物诱导性结肠炎的考虑对于诊断无法解释的腹至关重要.
- 早期识别和药物戒断有助于迅速管理和缓解MC的症状.
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