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当前吸入式烟草毒性评估模型的挑战:叙述性审查

Thivanka Muthumalage¹, Alexandra Noel², Yasmin Thanavala³

¹School of Health Sciences, Purdue University, West Lafayette, United States.

Tobacco induced diseases

|June 11, 2024

概括

新兴的烟草产品,如电子尼古丁输送系统 (ENDS) 和加热烟草产品 (HTP),需要标准化毒理评估. 该审查审查了当前的模型,并提出了可比风险估计和监管的建议.

科学领域:

新型烟草制品的毒理学和风险评估.

背景情况:

电子尼古丁输送系统 (ENDS) 和加热烟草制品 (HTP) 很受欢迎,作为传统吸烟的低风险替代品销售.
临床前模型 (体外,外生,内生) 用于评估这些新型产品的毒性和估计风险.
当前的研究方法存在显著差异,阻碍了数据的可比性和标准化.

研究的目的:

审查最先进的体外和体内模型来评估ENDS和HTP.
确定当前对新型烟草产品的毒理学评估和风险估计的挑战.
为毒理学参数提供建议,以确保研究可比性并支持监管批准.

主要方法:

对当前用于新兴烟草制品的体外和体内实验模型的综合文献综述.
分析现有的烟雾/气溶生成技术和喷气配置文件.
在研究研究中讨论数据生成和标准化方面的挑战.

主要成果:

目前的模型显示出相当大的变化,限制了对ENDS和HTPs的标准化,可比数据的生成.
现有的风险估计模型因方法不一致而面临挑战.
确定需要在毒理参数报告中标准化的关键领域.

结论:

在体外和体外模型和报告参数的标准化对于新兴烟草产品的可靠风险评估至关重要.
可比数据对于有效监管和监管机构对新型烟草产品的批准至关重要.
提供了建议,以提高ENDS和HTP的毒理学数据的一致性和可用性.

关键词:

电子烟是一种电子烟.加热烟草制品的加热烟草制品在体外和体内生物体内.吸入毒理学吸入毒理学电子烟 (vaping) 是一种电子烟.

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