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在欧洲人口中,肉类病与肝细胞癌风险的因果关系:孟德尔的随机化研究

Jiali Cao¹, Yumei Huang¹, Mengpei Zhu^1,2

¹Department of Gastroenterology, Liyuan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Frontiers in nutrition

|June 11, 2024

概括

下尾肌肉量 (ALM) 和手握力 (HGS) 在欧洲人中增加肝细胞癌 (HCC) 风险. C-反应蛋白 (CRP) 调解了这种关联,为萨科佩尼亚患者提供了潜在的缓解策略.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
代谢疾病代谢疾病

背景情况:

在欧洲人群中,萨科佩尼亚与肝细胞癌 (HCC) 风险和C反应蛋白 (CRP) 的调解作用的因果关系尚不清楚.
研究这些关联对于理解HCC病因和制定预防策略至关重要.

研究的目的:

通过使用孟德尔随机化 (MR) 在欧洲人口中调查肉类和HCC发病率之间的因果关系.
检查CRP在肉症-HCC关联中的潜在调解作用.
探索萨科佩尼亚和HCC之间的潜在反向因果关系.

主要方法:

进行了一种双向的两样,两步的门德尔随机化 (MR) 分析.
使用了HCC,CRP,尾肌肉量 (ALM),手握力 (HGS) 和步行速度 (WP) 的遗传总结统计数据.
为了确保稳定性,进行了施泰格测试,异质性和水平变性分析.

主要成果:

增加的ALM与降低的HCC风险相关 (OR:0.703,95%CI:0.524-0.943).
基因预测的低HGS与增加的HCC风险有关 (OR: 2.287,95% CI: 1.013-5.164),没有反向因果关系的证据.
在ALM和7.4%的低HGS对HCC风险的因果作用中,CRP占9.1%.

结论:

较低的ALM和较低的HGS与欧洲人的HCC风险增加有关.
在萨科佩尼亚指标和HCC之间的关系中,CRP充当了重要的调解者.
研究结果表明,在肉发症患者中降低HCC风险的潜在治疗点.

关键词:

在C-反应性蛋白质中.门德尔的随机化附的瘦肉质量附的瘦肉量抓地力抓地力抓地力抓地力肝细胞癌是肝细胞癌.这种类型的麻症是sarcopenia.

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