相关实验视频

Updated: May 13, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.3K

基于神经干细胞的高通量药物查发现S6K1抑制是Sonic hedgehog-medulloblastoma的选择性脆弱性

Leilei Zhou1, Niek van Bree1, Lola Boutin1

  • 1Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Neuro-oncology
|June 11, 2024
PubMed
概括

一项新的研究确定了PF4708671,一种S6K1抑制剂,作为声波刺髓母细胞瘤 (SHH-MB) 的向治疗方法. 这种化合物选择性地消除SHH-MB瘤细胞,同时保留健康的大脑细胞,提供了一个有前途的新治疗途径.

关键词:
PF4708671 的使用情况这就是S6K1的原因.高通量药物查屏幕的使用脑髓母细胞瘤是什么意思精确的癌症医学 精确的癌症医学

更多相关视频

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.5K
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

490

相关概念视频

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...