在使用intravoxel不连贯运动扩散权重成像的单边尿路阻塞鼠标模型中的对侧变化
Lingtao Zhang1, Xukai Mo1, Zijie Jiang2
1Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Renal failure
|June 11, 2024
概括
在尿路阻塞后,输入素不连贯运动 (IVIM) 显示出对侧脏的显著血液动力学变化. 皮层中的 perfusion 分数 (f) 是评估未受阻的脏中这些变化的关键指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 功能性磁共振成像 (fMRI) 研究往往忽略了单侧尿道阻塞 (UUO) 模型中的对侧脏变化.
- 了解这些相反的变化对于全面评估脏对阻塞的反应至关重要.
研究的目的:
- 评估intravoxel不连贯运动 (IVIM) 参数在检测皮层和对侧脏的髓中发生的变化的有用性.
- 在UUO的老鼠模型中调查IVIM参数和其病理学发现之间的相关性.
主要方法:
- 建立了一个单边尿路阻塞 (UUO) 鼠标模型.
- 进行了磁共振 (MR) 扫描,并测量了IVIM参数 (ADC,D,D*,f).
- 在阻塞后的不同时间点进行了组织病理学检查.
主要成果:
- 在阻塞的第10天,在皮层和脑髓中观察到明显扩散系数 (ADC) 的显著差异.
- 在第21天,皮层 perfusion 分数 (f) 在阻塞组和假组之间显示出显著的差异.
- 皮层f值对阻塞持续时间特别敏感,区分长时间和短时间的阻塞周期.
结论:
- 在脏阻塞后,在对侧脏中发生血液动力学变化.
- IVIM有效地表征了不受阻碍的对侧脏的功能和血液动力学变化.
- 皮层 perfusion 分数 (f) 显示出在 UUO 中评估 contralateral 脏修饰的高潜力.
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