使用生理学基础的药物动力学建模,对甲索特酸OATP和BCRP介导的药物相互作用进行综合评估

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Updated: Jun 24, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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Sejung Hwang1,2, Yujin Lee1, Yeonseo Jang1

  • 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea.

Clinical pharmacology and therapeutics
|June 11, 2024
PubMed
概括

使用PBPK建模研究了与甲基酸盐 (MTX) 的药物相互作用. 与利芬素或费布斯塔特同时使用显著增加了MTX暴露,突出显示了载体介导药物相互作用的重要性.

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