营养不良是结核病的危险因素之一
Juan Va Franco1, Brenda Bongaerts1, Maria-Inti Metzendorf1
1Institute of General Practice, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
The Cochrane database of systematic reviews
|June 11, 2024
概括
营养不良显著增加了结核病 (TB) 的风险,可能会在10年内翻一番. 解决营养不良问题对于全球结核病预防和控制工作至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 营养科学 营养科学
背景情况:
- 结核病 (TB) 仍然是全球主要的死亡原因,在2022年有1060万个新病例.
- 营养不良是一个重要的风险因素,在2022年导致220万例结核病发作.
研究的目的:
- 评估营养不良在预测结核病中的预后价值.
- 评估各种人群的风险,包括成年人,青少年和儿童.
主要方法:
- 一项系统性审查和对51项涉及超过2700万参与者的队列研究的元分析.
- 通过使用预后研究质量 (QUIPS) 工具评估研究的偏差.
- 随机效应元分析用于计算危险比率 (HR),风险比率 (RR) 和赔率比率 (OR).
主要成果:
- 营养不良与结核病风险增加有关 (HR 2.23).
- 对于10年以下的随访期 (HR 2.02) 风险更为一致和适度.
- 证据确定性通常是低到中等的,原因是研究中的偏见和不一致性.
结论:
- 营养不良可能会在短期 (<10年) 中增加结核病风险的两倍,也可能增加长期风险.
- 减少营养不良的政策对于到2030年结束结核病流行至关重要.
- 需要高质量的队列研究来完善风险估计,特别是在低收入国家和儿科人口中.
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