乳腺癌表观遗传学:当前和不断发展的治疗方法
Sujata Purja1,2, Dung Thuy Nguyen3, Eunyoung Kim4,5,6,7
1Central Research Center of Epigenome Based Platform and Its Application for Drug Development, College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea.
Breast cancer (Tokyo, Japan)
|June 11, 2024
概括
表观遗传药物对乳腺癌治疗有前途,越来越多的临床试验集中在HER2-负亚型上. 组合改善了无进展的生存率,为精准医学铺平了道路.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 临床试验 临床试验
背景情况:
- 乳腺癌 (BC) 治疗面临来自亚型特异性疗效限制和治疗耐药性的挑战.
- 表观遗传可塑性是一种动态和可逆的过程,显著影响治疗结果.
- 了解不断变化的表观遗传环境对于开发新的BC疗法至关重要.
研究的目的:
- 综合分析乳腺癌表观遗传学临床试验的趋势.
- 评估表观遗传药物 (epi-药物) 在BC治疗中的治疗潜力.
- 确定新兴策略和有前途的候选药物.
主要方法:
- 在ClinicalTrials.gov注册的BC表观遗传试验的横截面研究,直到2023年7月18日.
- 从注册表和PubMed.Med中获取随机对照试验结果.
- 分析试验数据,重点关注药物类型,组合,管理和患者群体.
主要成果:
- 在100项试验中研究了22种类药物;其中11种在38项正在进行的BC试验中.
- 希斯脱乙酶抑制剂占管道中药物的45.45%.
- 目前正在进行的试验侧重于HER2-阴性BC,经常将药与其他疗法结合起来.
- 在HR+/HER2-BC的III期试验中,图奇迪诺斯塔特和恩提诺斯塔特显示出更好的无进展生存期.
结论:
- 对BC表观遗传学日益增长的兴趣表明,人们正朝准确医学迈进.
- 对于持续的开发和批准,对有效性和安全性的强有力的证据是必要的.
- 表观遗传疗法有可能解决乳腺癌治疗的未满足需求.
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