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老化大脑中的光生物调节:从动物模型到人类的系统审查
Lucía Rodríguez-Fernández1, Candela Zorzo2, Jorge L Arias3
1Neuroscience Laboratory, Department of Psychology, University of Oviedo, Oviedo, Spain.
GeroScience
|June 11, 2024
概括
光生物调节 (PBM) 疗法在衰老期间有望改善认知功能和大脑健康. 这种非药理学方法可能有助于缓解与年龄相关的认知衰退,并增强大脑活动.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 衰老是一个复杂的生物过程,通常与认知能力下降有关.
- 光生物调制 (PBM) 是一种非药物疗法,对与年龄相关的认知障碍有潜在的益处.
- 本综述综合了关于PBM在衰老过程中的影响的临床前和临床证据.
研究的目的:
- 编译和分析现有关于老龄化人口光生物调节 (PBM) 的研究.
- 评估PBM对认知功能,行为和大脑修改在健康和病理衰老的影响.
- 评估有关PBM与年龄相关认知衰退的现有证据.
主要方法:
- 来自PubMed,Scopus和PsycInfo数据库的37项研究的系统审查.
- 对老化中的PBM进行临床前 (动物) 和临床 (人类) 研究的分析.
- 包括行为,神经心理和与大脑相关的结果措施.
主要成果:
- 在动物模型中,PBM显示了各种类型的记忆 (空间,情节性,社会) 的改善.
- 在人类中,PBM增强了健康老年人的工作记忆,认知抑制和词汇访问.
- PBM显示出逆转代谢变化的潜力,增强线粒体功能,并表现出神经保护作用.
结论:
- 光生物调制 (PBM) 疗法显示出显著的希望,作为一种非侵入性干预,用于增强衰老中的认知功能.
- PBM可能调节大脑功能重组,并为与年龄相关的认知障碍提供潜在的益处.
- 为了在衰老研究和临床实践中一致有效地应用PBM,需要标准化的协议.
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