阻塞性睡眠呼吸暂停对术后妄想的影响:一个系统审查和元分析
Yao Xiao1, Pei-Jun Li2, Meng-Yao Guo1
1West China School of Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan, PR China.
Sleep & breathing = Schlaf & Atmung
|June 11, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 可能会增加非ICU患者的术后妄想 (PD) 风险,但其在重症监护中的作用尚不清楚. 阳性气道压力 (PAP) 治疗疗法
科学领域:
- 医学研究 医学研究
- 睡眠医学 睡眠医学
- 关键护理医学 关键护理医学
背景情况:
- 手术后痴呆症 (PD) 是一种常见的并发症,特别是在老年患者中.
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的疾病,可能会影响外科手术后的结果.
- 需要进一步调查OSA和PD之间的关系.
研究的目的:
- 确定阻塞性睡眠呼吸暂停 (OSA) 对手术后痴呆症 (PD) 发生率的影响.
- 为了评估正气道压力 (PAP) 治疗在减少OSA患者的PD中的有效性.
主要方法:
- 在Embase,Cochrane图书馆和PubMed数据库进行系统的文献搜索,截至2022年11月27日.
- 使用随机效应模型进行元分析,以汇总符合条件的研究结果.
- 亚组和敏感性分析,以探索研究结果中的异质性.
主要成果:
- 包括16项研究. 13项研究表明,OSA显著增加了患PD的可能性 (OR = 1.71).
- 当通过非ICU特定尺度 (OR = 2.15) 评估时,OSA与PD增加有关,但不是CAM-ICU.
- 三项研究发现,PAP治疗没有显著降低PD发病率 (OR = 0.58).
结论:
- 在重症患者中,OSA可能不是PD的风险因素,但在非ICU环境中可能会增加PD风险.
- PAP治疗在减轻OSA患者PD的疗效仍然不确定,需要进一步研究.
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