患有心房 Septal 缺陷的儿童的左心室透析功能,通过增加液压力的手段,在关闭后得到改善
Pia Sjöberg1,2, Henning Clausen3,4, Håkan Arheden5,6
1Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. pia.sjoberg@med.lu.se.
Pediatric cardiology
|June 11, 2024
概括
患有心房隔膜缺陷 (ASD) 的儿童表现出改变的液压力,影响左心室透静填充. 自闭症的关闭改善了这种力,但它仍然低于健康儿童,这表明持续的扩张性异常.
科学领域:
- 心血管生理学心血管生理学
- 儿童心脏病学 儿童心脏病学
- 医疗成像医学成像
背景情况:
- 液压力,由心房心房面积差 (AVAD) 确定,有助于左心室 (LV) 的透气填充.
- 前庭隔膜缺陷 (ASD) 可以减少 LV 填充由于左向右的分流,可能改变液压力.
研究的目的:
- 评估AVAD和液压力是否在与对照组相比,在患有自闭症的儿童中有所不同.
- 评估ASD关闭是否改善小儿病患者的AVAD和液压力.
主要方法:
- 心脏磁共振成像 (CMR) 用于在短轴视图中划分左心房和心室区域.
- 房面积差 (AVAD) 被计算并将其正常化为身体高度 (AVADi).
- 儿童与ASD (关闭前和关闭后) 和健康对照进行了比较.
主要成果:
- 与对照组相比,患有自闭症的儿童在自闭症关闭之前和之后的正常化AVADi显著降低.
- 在ASD关闭后AVADi有所改善,表明增强了液压力和LV扩张功能.
- 尽管情况有所改善,但AVADi在关闭后的ASD患者中仍然低于对照组,这表明残留的扩张性异常.
结论:
- 在ASD关闭后的儿童中,左心室透静功能得到改善,通过增强的液压力 (AVAD) 介导.
- 关闭后持续较低的AVADi突出显示持续的透析异常,即使在ASD成功修复后也是如此.
- 考虑关闭ASD的患者较小的分流,特别是年幼的儿童,可能是有必要的,以防止腹功能障碍和改善长期的结果.
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