对新诊断的移植不合格多发性骨髓瘤的治疗方法的临床共识:双盲的Delphi小组
Rafael Fonseca1, Adriana Rossi2, Rohan Medhekar3
1Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Phoenix, AZ, USA.
Future oncology (London, England)
|June 11, 2024
概括
对于新诊断的多发性骨髓瘤移植不合格的患者,专家共识强调患者因素和治疗疗效在一线处方中. 含达拉图穆马布的疗法被认为对这些新诊断的多发性骨髓瘤患者最有效.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床实践 临床实践
背景情况:
- 新诊断的多发性骨髓瘤 (NDMM) 对移植不合格 (TIE) 患者提出了独特的挑战.
- 第一线治疗选择显著影响TIE NDMM的结果.
研究的目的:
- 在影响TIE NDMM第一线处方决策的关键因素上达成临床共识.
- 确定对TIE NDMM最有效的初始治疗策略的专家意见.
主要方法:
- 使用了经过修改的Delphi面板方法.
- 专家小组成员包括美国的血液学家/瘤学家,他们专门从事TIE NDMM治疗.
- 该研究采用双盲方法收集专家意见.
主要成果:
- 共识确定了患者的脆弱性,表现状况和并发症作为关键的处方因素.
- 治疗疗效和不良事件概况也被确定为关键考虑因素.
- 88%的专家认为含达拉图穆马布的疗法是TIE NDMM最有效的第一线选择.
结论:
- 临床共识支持优先考虑TIE NDMM前期治疗中的疗效.
- 专家普遍认为,含达拉图穆马布的疗法是TIE NDMM初始治疗中最有效的选择.
- 建议继续治疗,只要好处超过风险,直到疾病进展为止.
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