小天花疫苗接种活动导致与年龄相关的人口对麻疹病毒的交叉免疫
Kieran Dee1, Maria Manali1, Laura A Bissett1
1MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK.
The Journal of general virology
|June 11, 2024
概括
来自天花疫苗接种的抗体提供了对病毒 (MPXV) 的交叉保护. 1971年以前出生的人具有较高的MPXV中和抗体,这表明年龄是Mpox感染的危险因素.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 猿病毒 (MPXV) 的人与人传播是一个日益严重的公共卫生问题.
- 众所周知,针对用于天花疫苗接种的病毒疫苗病毒 (VACV) 生成的抗体可以提供对MPXV的交叉保护.
研究的目的:
- 在人类群体中调查抗体介导对MPXV的交叉中和程度.
- 为了确定先前的天花疫苗接种是否影响MPXV中和能力.
主要方法:
- 使用了电化学发光免疫测试 (ECLIA) 和活病毒中和测试.
- 分析了来自苏格兰患者群体的430个血清样本.
主要成果:
- 在英国天花疫苗接种常规时出生的个人表现出更高水平的抗体,能够交叉中和MPXV.
- 在出生年和MPXV中和抗体标位之间观察到相关性.
结论:
- 年龄,特别是出生于1971年以后,被确定为对Mpox感染易感性增加的重要危险因素.
- 过去的天花疫苗接种状态是针对MPXV的交叉保护性免疫力的关键决定因素.
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