植物共生形成皮肤细菌群落和病原体保护功能在阿巴拉契亚 salamanders
Owen G Osborne1, Randall R Jiménez2,3, Allison Q Byrne2,4
1School of Environmental and Natural Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2DG, United Kingdom.
The ISME journal
|June 11, 2024
概括
宿主与微生物组之间的联系 - - 生物共生 - - 是由宿主特征驱动的,而不是微生物,在阿巴拉契亚山中. 这影响了真菌病原体 (Batrachochytrium dendrobatidis) 的动态,并提供了益生菌的潜力.
科学领域:
- 生态生态学 生态生态学
- 进化生物学 进化生物学
- 微生物组研究 微生物组研究
背景情况:
- 生物共生 (phylosymbiosis) 描述了与宿主相关的微生物组合与宿主基因构成一致的模式.
- 了解植物共生驱动因素对于疾病生态学和微生物组操纵至关重要.
- 宿主特征,息地,饮食和宿主微生物的共同多样化可以塑造生物共生.
研究的目的:
- 为了量化阿巴拉契山皮肤微生物组中的生物共生.
- 评估宿主类型,环境和真菌病原体 (Batrachochytrium dendrobatidis - Bd) 感染对皮肤微生物群的影响.
- 探索与疾病有关的宿主微生物群相互作用的生态进化动态.
主要方法:
- 采集了10种阿巴拉契亚山的样本 (>1亿5千万年差异).
- 对Batrachochytrium dendrobatidis (Bd) 感染状况的评估.
- 皮肤和环境微生物组组成的分析.
主要成果:
- 检测到一种显著的生物共生信号,主要是由影响微生物组组装的宿主特征驱动的,而不是宿主-微生物共同物种化.
- 当地的环境微生物群,气候,地理和Bd感染负载对植物共生有很小的影响.
- Bd感染与宿主基因和Bd抑制细菌的丰富性相关,这表明长期的宿主微生物组动态影响病原体分布.
- 五种Bd抑制性细菌菌株表现出广泛的宿主和息地泛性,表明益生菌应用的潜力.
结论:
- 宿主类型显著塑造了沙兰皮肤微生物组合,超过了环境影响.
- 萨拉曼德 - 微生物群相互作用的生态进化历史影响了当前的疾病动态和病原体传播.
- 总体而言,Bd抑制性细菌是基于微生物组的保护策略的潜在候选者.
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