产后母亲护理可以缓和产前双暴露对后代神经发育,行为和转录学结果的影响
Samantha C Lauby1,2, Hannah E Lapp1, Melissa Salazar1
1Department of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, Texas, United States of America.
PloS one
|June 11, 2024
概括
产前接触双醇 (BP) 影响神经发育,但这种影响取决于母亲的照顾. 优质的产后护理可以减轻老鼠早期BP暴露的不良结果.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 双 (BP),包括BPA和"无BPA"类似物,是塑料中发现的内分泌干扰化学物质.
- 产前BPA暴露与不良的神经发育和行为结果以及受损的孕产妇护理有关.
- 关于非BPA双和产前BP暴露和产后母亲护理的综合影响的数据有限.
研究的目的:
- 调查产前双暴露和产后母亲护理对大鼠神经发育和行为的相互作用影响.
- 探索潜在的分子机制,包括转录原子变化.
主要方法:
- 在产前,老鼠暴露在双醇中.
- 产后母亲的护理是在生命的前五天被评估的.
- 评估了神经发育 (开眼) 和成人行为 (注意力设置转移,焦虑).
- 进行了中部前额叶皮层和杏仁核的转录形状分析.
主要成果:
- 产前双暴露对眼睛开放,注意力和焦虑的影响是由母亲的护理调节的.
- 孕产妇的护理可以减轻产前双暴露的一些不良影响.
- 转录组数据表明,雌激素受体信号传递和基因表达途径的趋同.
结论:
- 产后母亲护理对于调解产前双暴露的神经发育和行为影响至关重要.
- 了解这些相互作用可能会揭示减轻双醇不良影响的策略.
- 雌激素受体信号传递和基因表达是关键的生物通路.
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