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Updated: Jul 8, 2026

Microcrystallography of Protein Crystals and In Cellulo Diffraction
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使用无细胞蛋白质结晶的高通量结构确定一种内在无序的蛋白质

Mariko Kojima1, Satoshi Abe1, Tadaomi Furuta1

  • 1School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8501, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|June 11, 2024
PubMed
概括

我们开发了一种快速的无细胞蛋白质结晶方法,以确定内在无序蛋白质 (IDP) 的原子结构. 这项技术确定了两个关键的疏水性残留物,稳定了c-Myc蛋白.

关键词:
在X射线晶体学.无细胞蛋白质结晶的过程本质上是无序的蛋白质.纳米晶体的使用方法

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Protein Organization01:13

Protein Organization

Overview
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Protein Folding

Overview
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
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