患有扩散型大B细胞淋巴瘤的患者的心血管死亡率:基于人口的研究
Danhua Hong1, Mengzhuo Yin1, Jie Li1
1Department of Geriatrics, School of Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Leukemia & lymphoma
|June 11, 2024
概括
心血管疾病是扩散性大B细胞淋巴瘤 (DLBCL) 患者的重大风险. 近几十年来,年轻患者患心脏病的死亡率有所增加,某些治疗方法会使预后恶化.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种常见的非霍奇金淋巴瘤.
- 心血管疾病 (CVD) 是癌症患者已知的并发症.
- 了解DLBCL中心血管疾病死亡率对于患者管理至关重要.
研究的目的:
- 在DLBCL患者中调查心血管死亡风险.
- 分析美国近几十年心血管疾病死亡率的趋势.
- 确定DLBCL中心血管死亡率的预后因素.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (1975-2019) 的数据.
- 包括被诊断患有DLBCL的成年患者.
- 雇佣标准化死亡率,结合点回归和竞争风险模型.
主要成果:
- 在49918名DLBCL患者中观察到4167例 (8.3%) 的心血管死亡.
- 心血管疾病死亡率是预期的1.22倍.
- 基于发病率的心血管死亡率每年增加0.98% (1985-2019),特别是在75岁以下的人群中.
- 年龄较大,男性性别,早期诊断,较低的瘤阶段,化疗,放射治疗和手术与较差的心血管结果有关.
结论:
- 患有DLBCL的患者面临心血管死亡风险升高.
- 心血管疾病死亡率一直在增加,特别是在年轻人群中.
- 治疗方式和患者因素在DLBCL中显著影响心血管死亡率.
相关概念视频
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This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Lymphoid Cells and Tissues
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Primary Lymphoid Organs
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The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...


