脑损伤的血生物标志物及其与脑MRI和1型糖尿病认知的关联
Amy B Karger1, Ilya M Nasrallah2, Barbara H Braffett3
1Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Diabetes care
|June 11, 2024
概括
神经纤维光链 (NfL) 是1型糖尿病 (T1D) 的关键生物标志物,与加速的大脑衰老和认知问题有关. 在T1D中早期的神经退行可能不涉及类似阿尔茨海默氏症的途径.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 生物标志物研究 生物标志物研究
背景情况:
- 1型糖尿病 (T1D) 与认知能力下降和大脑变化的风险增加有关.
- 神经退行症的等离子体生物标志物在T1D等慢性疾病中越来越多地被研究.
研究的目的:
- 研究大脑损伤的血生物标志物与T1D成年人的神经影像/认知结果之间的关系.
- 为了确定这些生物标志物是否与T1D中的阿尔茨海默病 (AD) 样病理一致.
主要方法:
- 在373名DCCT/EDIC参与者中分析了粉样蛋白-β-40,粉样蛋白-β-42,神经纤维光链 (NfL),酸化Tau-181 (pTau-181) 和状纤维酸蛋白 (GFAP) 的血水平.
- 利用MRI进行大脑体积,白质完整性和大脑年龄预测.
- 使用记忆和效率测试评估认知功能.
主要成果:
- 较高的NfL水平与预测的大脑年龄的增加以及认知障碍的更高几率相关.
- NfL和pTau-181与心理运动和心理效率降低有关.
- 升高的HbA1c水平与增加的NfL和pTau-181有关.
- 粉样β生物标志物没有显示出任何显著的关联.
结论:
- 血生物标志物在这个老化的T1D队列中没有表明类似AD的个人资料.
- NfL是T1D的重要生物标志物,与血糖控制,加速大脑衰老和认知功能障碍有关.
- 这表明非AD/非粉样蛋白机制可能参与T1D早期神经退行.
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