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在GC-MS分析过程中,分析保护剂的方法是保护基于胺基的合成大麻素免受降解和化

Khaled Masoud Mohamed Masoud¹, Syed Mujeebuddin Syed¹, Alanoud Mosa Alasiri¹

¹Forensic Chemistry Laboratory, Department of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia.

Journal of chromatography. A

|June 11, 2024

概括

气色谱-质谱法 (GC-MS) 导致胺基合成大麻素 (SCs) 的热降解. 在甲醇中使用比醇等分析保护剂 (AP) 可以防止降解,并提高SCs的分析灵敏度.

科学领域:

法医化学法医化学
分析化学分析化学
质谱测量质量谱测量

背景情况:

气色谱-质谱法 (GC-MS) 是分析合成大麻素 (SCs) 的标准.
基于胺的SCs在GC-MS期间容易发生热解降解,这使分析复杂化.
了解降解途径对于准确的法医识别至关重要.

研究的目的:

在GC-MS期间调查基于胺基的SCs的热降解和转化.
评估分析保护剂 (AP) 在减轻降解和改进分析方面的有效性.
为了表征特定的SCs的降解产品和化产品.

主要方法:

使用GC-MS与各种注射溶剂 (非酒精,甲醇) 的AB-FUBINACA,AB-CHMINACA和MAB-CHMINACA的分析.
用分析保护剂 (AP) 进行处理,具体是甲醇中的0.5%索尔比托.
验证AP增强方法的灵敏度,线性,准确性和精度.

主要成果:

在非酒精溶剂中降解的基于胺基的SCs;甲醇导致化为新的SCs.
降解和化与通过键在玻璃羊毛上的吸附有关.
甲醇 (AP) 中的0.5%索伯完全保护了SCs,改善了色谱形状,增加了敏感度的十倍.
方法验证显示出优异的线性,精度 (<11%) 和精度 (<13%),检测极限为25 ng/mL.

结论:

分析剂保护剂,特别是甲醇中的,在GC-MS期间有效防止胺基SCs的热降解和化.
开发的方法提高了在各种矩阵中对SC的法医分析的灵敏度和可靠性.
这种方法为准确识别和定量合成大麻素提供了显著的改进.

关键词:

分析剂保护剂分析剂保护剂降解降解是一种降解.化的化方法法医分析法医分析在GC-MS中使用GC-MS.玻璃羊毛是一种玻璃羊毛.

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