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在人体体内使用的人类膝关节-加载装置,用于基于MRI的内脏组织应变和放松度分析

Hongtian Zhu¹, Emily Y Miller², Woowon Lee¹

¹Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.

Journal of biomechanics

|June 11, 2024

概括

一种新的MRI设备应用膝盖负荷来测量软骨变形,从而能够早期发现骨关节炎. 这项创新有助于通过识别生物机械生物标志物来开发改变疾病的治疗方法.

科学领域:

生物医学工程生物医学工程
整形外科整形外科整形外科
医疗成像医学成像

背景情况:

早期的骨关节炎诊断具有挑战性,阻碍了对新治疗方法的评估.
承受负荷的软骨变形模式可以作为早期疾病生物标志物.
缺乏使用MRI进行体内软骨生物机械分析的全面工作流程.

研究的目的:

开发和验证一种装置,用于在MRI扫描仪内在体内施加Varus-valgus膝盖负荷.
为了使软骨结构和机械功能在负载下进行定量MRI测量.
建立一个实用的工作流程,用于识别和验证早期骨关节炎的生物机械成像生物标志物.

主要方法:

设计了一种装置,可以在体内3T磁共振成像环境中对人类膝盖施加瓦鲁斯-瓦尔古斯负荷.
该设备在实验室环境中进行了测试,然后在 varus 加载期间在人体中进行了测试.
螺旋密度MRI与加载装置集成,以捕获依赖于时间的带带的位移和应变图.

主要成果:

装载装置成功实现了在联合装载过程中对生物力学和放松度的定量MRI采集.
该装置促进了膝关节中部部位的压缩,与负荷相一致.
与螺旋DENSEMRI集成提供了依赖时间的移位和应变图,证明了软骨变形.

结论:

开发的膝盖负荷装置符合体内生物机械分析的设计标准.
这种工作流对于未来涉及临床队列的研究来说是实用的.
这项技术可以识别和验证基于成像的生物机械生物标志物,用于早期发现骨关节炎.

关键词:

软骨和软骨是一种膝关节:膝关节的关节是指膝关节的关节,膝关节是指膝关节的关节.骨关节炎是一种骨关节炎.压力测试是一种压力测试.这种QMRI是QMRI

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