棕乙烯胺和氨酸治疗后传染性嗅觉障碍:其效果在临床上有多重要?
Janine Gellrich1,2,3, Linda Czaplewski1, Antje Hähner1
1Smell and Taste Clinic, Department of Otorhinolaryngology, Dresden, Germany.
概括
与嗅觉训练 (OT) 结合的棕甲基乙醇胺 (PEA) 和黄素 (LUT) 显示,后病毒嗅觉功能障碍有所改善. 然而,与单独的OT相比,额外的益处在临床上并不显著.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 病毒后嗅觉功能障碍,特别是COVID-19后,是一个日益严重的临床问题.
- 嗅觉训练 (OT) 是一种标准疗法,但正在探索新的治疗方法.
- 棕乙醇胺 (PEA) 和黄 (LUT) 具有抗炎性质,具有潜在的治疗应用.
研究的目的:
- 研究将PEA-LUT与OT结合用于治疗病毒后嗅觉功能障碍的疗效.
- 为了比较OT与PEA-LUT与单独OT对嗅觉损失的患者的影响.
主要方法:
- 进行了一项随机对照试验,其中50名患者患有持续的嗅觉功能障碍.
- 参与者被分配到使用PEA-LUT或单独使用OT的OT中.
- 在治疗前和治疗后评估了嗅觉功能.
主要成果:
- 接受PEA-LUT和OT的组在气味歧视和TDI得分方面显示出统计学上显著的改善.
- 对照组 (仅OT) 没有显著改善.
- 在临床上有意义的改善在两组之间没有显著差异.
结论:
- PEA-LUT可能为后病毒性功能障碍中的嗅觉功能提供潜在的益处,但它对单独的OT的附加值似乎有限.
- 这些发现需要进一步调查,与之前的一些研究相反.
- 该研究强调了在嗅觉功能障碍研究中需要临床相关的结果测量.
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