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Updated: Jun 24, 2025

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Published on: May 29, 2021

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一个扩大的碎片结合结构的扩展库,用于全酶PTP1B,来自大规模晶体学数据的计算再分析

Tamar Mehlman1, Helen M Ginn2, Daniel A Keedy3

  • 1Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031, USA; PhD Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA.

Structure (London, England : 1993)
|June 11, 2024
PubMed
概括

研究人员发现了65个新的蛋白质氨酸酸酶1B (PTP1B) 的碎片命中,这是糖尿病和癌症的关键目标. 结晶学数据的计算分析揭示了隐藏的蛋白质状态和新型的全性机制,推动了药物发现工作.

关键词:
这就是PTP1B.在X射线晶体学.一个全osteric 连接体.亚洛斯特菌是什么意思?计算式晶体学 计算式晶体学碎片选 碎片选 碎片选 碎片选酸酶是一种酸酶.蛋白质结构 蛋白质结构

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