创伤后应激障碍患者的个人治疗选择:对个性化优势指数的外部验证
James Tait1, Stephen Kellett2, David Saxon3
1School of Psychology, University of Sheffield, ICOSS Building, 219 Portobello, Sheffield, S1 4DP, United Kingdom.
概括
对创伤后应激障碍 (PTSD) 治疗选择的个性化优势指数 (PAI) 模型没有准确地预测新组患者的结果. 这种PAI模型未能将其推广到外部验证样本.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 计算精神病学是一种计算精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 治疗选择可能具有挑战性.
- 个性化医疗方法旨在优化治疗分配.
- 个性化优势指数 (PAI) 模型是为了预测PTSD治疗成功而开发的.
研究的目的:
- 评估PTSD治疗选择的PAI模型的预测准确性和概括性.
- 在独立的数据集上验证 PAI 模型.
- 为了比较PAI指示的最佳和次优治疗之间的结果.
主要方法:
- 使用了由Deisenhofer等人开发的PAI模型. (2018年) 的时间.
- 将模型应用于152名PTSD患者的数据集,这些患者接受了以创伤为重点的认知行为疗法或眼动脱敏和再处理.
- 基于PAI指示治疗分配的治疗结果进行比较.
主要成果:
- 该PAI模型没有提供治疗特异性的预测.
- 接受PAI指定的最佳治疗的患者与接受次优治疗的患者相比,没有显示出明显更好的结果.
- 该模型的性能在外部验证样本中没有保持.
结论:
- 经测试的PAI模型没有在PTSD治疗的外部验证样本中显示出预测准确性或概括性.
- 这些发现表明,目前PAI模型在常规临床环境中的适用性存在局限性.
- 需要进一步的研究来开发可靠的PTSD治疗选择预测模型.
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