在COPD前可治疗的特征:现在是时候将可治疗的特征范式扩展到既定疾病之外
Shyamali C Dharmage1, Rosa Faner2,3,4, Alvar Agustí3,4,5,6
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Respirology (Carlton, Vic.)
|June 11, 2024
概括
可治疗特征 (TTs) 方法现在可以在诊断之前应用,特别是在慢性阻塞性肺病 (COPD) 之前. 对这些特征的早期干预可以防止疾病的进展.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 预防性医疗保健 预防性医疗保健
- 基因组学和环境相互作用
背景情况:
- 可治疗特征 (TTs) 方法,专注于临床特征和风险因素,越来越多地用于诊断疾病.
- 越来越需要将TT方法扩展到疾病的临床前阶段,以使早期干预成为可能.
研究的目的:
- 建议及时应用TT方法对临床前疾病状态.
- 探索在慢性阻塞性肺病前期 (COPD前期) 针对TT的潜力,以预防疾病的发展.
主要方法:
- 对终身肺功能轨迹的最新知识的审查.
- 整合"GETomics"概念框架 (基因,环境和时间) 以了解疾病病因.
- 讨论目前关于COPD前的TT的证据,以及实践和研究的建议.
主要成果:
- 在空气流量限制发展之前,COPD前患者表现出可治疗的特征.
- 该GETomics框架提供了关于COPD前相关的基因环境相互作用的见解.
- 有证据支持在COPD前确定潜在的TT.
结论:
- 在COPD前应用TT方法是预防疾病的有希望的策略.
- 这种方法可能会振兴呼吸系统健康的预防策略.
- 对COPD前的TT进行进一步的研究是有必要的,以优化临床实践.
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