在短时间的太空飞行后,Secretome 概况显示了氧化应激,大脑平衡和凝血的急性变化
Nadia Houerbi1,2, JangKeun Kim1,2, Eliah G Overbey1,2
1Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Nature communications
|June 11, 2024
概括
太空飞行会改变宇航员的健康指标,影响凝血和压力. 虽然一些血标记物恢复,但其他标记物仍然存在,这凸显了针对性对策的必要性.
科学领域:
- 生物医学科学 生物医学科学
- 太空医学 太空医学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 商业航天飞行日益增加,需要强大的宇航员健康监测.
- 基于血液的生物标志物对于理解太空飞行的生理影响和制定对策至关重要.
研究的目的:
- 分析宇航员血液生物标志物,以评估太空飞行期间和之后的生理变化.
- 为了识别与太空飞行暴露相关的特定分子特征.
主要方法:
- 来自SpaceX Inspiration4船员的血蛋白,代谢物和细胞外囊泡/粒子 (EVPs) 的分析.
- 分析太空飞行小鼠大脑中的蛋白质组变化,以调查血脑屏障 (BBB) 的完整性.
主要成果:
- 太空飞行引发了凝血,氧化应激和大脑丰富蛋白质的显著变化.
- 大多数囊泡和代谢物变化在六个月内消失,但73%的血蛋白变化在飞行后持续存在.
- 蛋白质组变化与外围血液单核细胞比全血更强烈相关,太空飞行小鼠显示PECAM-1增加,表明BBB中断.
结论:
- 短时间的太空飞行显著破坏了人类和小鼠的生理学.
- 基于血液的分泌基因分析揭示了持续的分子扰动和潜在的BBB破坏.
- 已识别的太空飞行生物标志物可以指导为宇航员健康制定有效的对策.
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