儿童侵略的遗传学,一个系统的审查
Emiko Koyama1,2, Tuana Kant1, Atsushi Takata2
1Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Translational psychiatry
|June 11, 2024
概括
遗传因素影响儿童的侵略性,但确切的生物机制仍然不清楚. 这次审查强调了需要进行更大规模,多样化的研究,使用一致的方法来了解青少年侵略的遗传基础.
科学领域:
- 儿童精神病学和发育神经科学
- 行为遗传学和分子精神病学
背景情况:
- 儿童的攻击性是一个普遍的行为问题,导致精神病学转诊.
- 遗传因素约占儿童侵略差异的一半.
- 正确的生物学机制和基因与环境的相互作用是侵略的基础,尚未完全理解.
研究的目的:
- 系统地审查关于儿童侵略性遗传学的现有研究,独立于精神病学诊断.
- 提供对研究的概述,研究对青少年侵略性行为的遗传影响.
主要方法:
- 在PubMed,PsycINFO和MEDLINE数据库中的系统文献搜索.
- 包括使用与侵略,基因和儿童/青少年人口相关的关键词的研究.
- 从652的初始产量中提取和评估87项相关研究的质量.
主要成果:
- 候选基因研究,特别是那些专注于MAOA,DRD4和COMT的研究,很普遍.
- 越来越多地使用全基因组关联和表观遗传学研究设计.
- 由于研究规模适度,可变评估方法和不一致的变异分类,关于遗传主要影响和相互作用的不确定的发现很常见.
- 大多数研究集中在欧洲人群上,大多数研究涉及男性参与者.
结论:
- 目前关于儿童侵略性遗传学的研究得出了不确定的结果.
- 以更大,多样化的样本,标准化的评估和明确的表型定义进行进一步的研究至关重要.
- 探索各种方法,如表观遗传学,转录学和纵向研究,对于阐明侵略的生物学基础至关重要.
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