抗VEGF治疗黄斑新血管化的4年结果中的病理和非病理高近视之间的差异
Yuki Honda1, Manabu Miyata2, Masahiro Miyake1
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto City, Kyoto Prefecture, 606-8507, Japan.
Scientific reports
|June 11, 2024
概括
针对近视性黄斑新血管化 (MNV) 的抗VEGF治疗显示,在病态近视 (PM) 和非PM眼睛中,类似的4年视力敏度结果. 然而,非PM眼睛需要更多的注射,需要更密切的监测.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗视网膜 医学视网膜
背景情况:
- 高近视的斑点新血管化 (MNV) 是一个重大挑战.
- 了解病理近视 (PM) 和非PM之间的治疗差异对于有效管理至关重要.
研究的目的:
- 为了比较拉尼比祖马布或阿弗利伯塞普治疗近视性MNV的4年结果,在患有和没有病态近视 (PM) 的患者中.
- 评估两组治疗要求和视力敏度之间的差异.
主要方法:
- 对118个未接受过治疗的眼睛进行了回顾性观察研究,这些眼睛患有活跃近视性MNV,并接受了内拉尼比祖马布或阿弗利伯塞普的治疗.
- 根据META-PM研究标准,眼睛被分为非PM和PM组.
- 随访和最佳校正的视力敏度 (BCVA) 在4年内使用预先预测 (PRN) 方案进行评估.
主要成果:
- 最初的BCVA在非PM组在1年和2年后更好,但4年的BCVA课程在非PM和PM组之间是相似的.
- 与PM组相比,非PM组在4年内需要注射的次数显著增加 (4.6对2.9).
- 基线BCVA是两组4年BCVA的唯一显著预测因素.
结论:
- 对近视性MNV的抗VEGF治疗在非PM和PM眼睛中产生了可比的4年视觉结果.
- 与PM眼相比,非PM眼需要在PRN方案下更频繁的注射.
- 建议对非PM眼睛进行更密切的跟踪,以保持长期的视力敏度.
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