减少的嗅球体积伴随着轻微的SARS-CoV-2感染后的嗅觉功能障碍
Marvin Petersen1, Benjamin Becker2, Maximilian Schell3
1Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. mar.petersen@uke.de.
Scientific reports
|June 11, 2024
概括
COVID-19的嗅觉障碍与减少的嗅觉球体体积有关. 这一发现表明,嗅球的大小可以帮助诊断和指导感染后长期嗅觉功能障碍的康复.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 嗅觉障碍是COVID-19的一个常见但鲜为人知的症状.
- 了解嗅觉功能障碍的决定因素对于患者管理至关重要.
研究的目的:
- 调查嗅球体积与COVID-19相关的嗅觉障碍的临床过程之间的关联.
- 在COVID-19康复者中识别嗅觉功能障碍的潜在成像生物标志物.
主要方法:
- 一项大型磁共振成像 (MRI) 研究分析了233名未接种疫苗的COVID-19康复者的数据.
- 进行了基线MRI,神经心理测试和嗅觉功能问卷.
- 后续评估包括使用Sniffin' Sticks进行定量嗅觉测试.
主要成果:
- 自我报告的嗅觉功能障碍的患病率从急性感染期间的67.1%下降到随访时的17.5%.
- 持久性嗅觉功能障碍的个体在基线时嗅觉球体体积显著减少.
- 基线嗅觉球体体积预测了随访时的嗅觉计分数,而神经心理学表现没有显示出显著的关联.
结论:
- 嗅球体积与从COVID-19中恢复过来的个体的长期嗅觉功能障碍有关.
- 嗅球完整性是诊断和管理COVID-19后嗅障碍的潜在代用标记.
- 这些发现可能会为患有持续嗅觉丧失的患者提供康复策略.
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