在非严重的SARS-CoV-2感染后认知功能的元分析
Tara A Austin1,2,3, Michael L Thomas4, Min Lu5
1The VISN 17 Center of Excellence for Research on Returning War Veterans, 4800 Memorial Drive, Waco, TX, 76711, USA. tara.austin@va.gov.
Neuropsychology review
|June 11, 2024
概括
从轻度到中度的COVID-19中恢复过来的个人表现出客观认知障碍. 认知功能比健康个体更差,但在较不严重的初始感染中得到改善,这表明认知干预的潜在益处.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 主观认知症状在COVID-19 (PASC) 后急性后果中很常见.
- 在非严重的SARS-CoV-2感染后的客观认知障碍需要进一步调查.
- 在轻度/中度COVID-19后,对客观认知功能没有先前的元分析.
研究的目的:
- 在后急性阶段对非严重 (轻度/中度) COVID-19 患者的客观认知障碍进行元分析.
- 描述非严重SARS-CoV-2感染后个体的认知表现.
主要方法:
- 根据PRISMA指南进行的元分析.
- 在普罗斯佩罗预先注册 (CRD42021293124).
- 至少两名独立审稿人对59篇文章 (22,060名参与者) 进行选和数据提取.
主要成果:
- 患有非严重COVID-19的个体表现出比健康对照者更差的客观认知表现.
- 与中度 (住院) 或严重 (ICU) 病例相比,轻度 (非住院) 病例的认知表现更好.
- 观察到很高的异质性,可能是由于样本大小小和方法变化.
结论:
- 从不严重的COVID-19中恢复可能会造成认知能力下降或受损的风险.
- 在COVID-19后的个人可能会从有针对性的认知健康干预中受益.
- 需要进一步研究更大的样本大小和标准化的方法.
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